InterPAD - DETAILS

arsenic trioxide, Arsenic oxide (As2O3), arsenic(3+);oxygen(2-), Arsenic(III) trioxide, Arsenic oxidearsenous trioxide, DTXSID0020103, Arsenous oxide [ISO], Arsenious Acid Anhydride, RCRA waste no. P012, EINECS 215-481-4, UN1561, Arsenic trioxide [USAN:JAN], DTXCID60820620, QTLQKAJBUDWPIB-UHFFFAOYSA-N, Tox21_112255, Arsenic trioxide [UN1561] [Poison], CAS-1327-53-3, NS00076140, EC 215-481-4, SR-01000944371, SR-01000944371-1

No.	Title	Href
1	Curcumin combined with arsenic trioxide in the treatment of acute myeloid leukemia: network pharmacology analysis and experimental validation. J Cancer Res Clin Oncol. 2023 Jan;149(1):219-230. doi: 10.1007/s00432-022-04463-7.	`Click`
2	Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis. Leuk Lymphoma. 2015;56(11):3159-67. doi: 10.3109/10428194.2015.1011155.	`Click`

No.

Title

Href

Curcumin combined with arsenic trioxide in the treatment of acute myeloid leukemia: network pharmacology analysis and experimental validation. J Cancer Res Clin Oncol. 2023 Jan;149(1):219-230. doi: 10.1007/s00432-022-04463-7.

Click

Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis. Leuk Lymphoma. 2015;56(11):3159-67. doi: 10.3109/10428194.2015.1011155.

Click

Name	Arsenic trioxide
PubChem CID	14888
Molecular Weight	197.841g/mol
Synonyms	arsenic trioxide, Arsenic oxide (As2O3), arsenic(3+);oxygen(2-), Arsenic(III) trioxide, Arsenic oxidearsenous trioxide, DTXSID0020103, Arsenous oxide [ISO], Arsenious Acid Anhydride, RCRA waste no. P012, EINECS 215-481-4, UN1561, Arsenic trioxide [USAN:JAN], DTXCID60820620, QTLQKAJBUDWPIB-UHFFFAOYSA-N, Tox21_112255, Arsenic trioxide [UN1561] [Poison], CAS-1327-53-3, NS00076140, EC 215-481-4, SR-01000944371, SR-01000944371-1
Drug Type	Small molecule
Formula	As₂O₃
SMILES	[O-2].[O-2].[O-2].[As+3].[As+3]
InChI	1S/2As.3O/q2+3;3-2
InChIKey	QTLQKAJBUDWPIB-UHFFFAOYSA-N
CAS Number	1327-53-3
TTD ID	D07VIK
Drug Bank ID	DB01169
KEGG ID	C13619
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Curcumin, Arsenic trioxide
Partner Name	Curcumin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	JAK2	hsa3717
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Expression	STAT3	hsa6774
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
In Vivo Model	All mice were inoculated with KG1-a cells via the tail vein after pretreatment of 48 h, approximately 1.0×10⁷ cells per mouse.
Result	Our results suggested that curcumin and As2O3 combination therapy exerts more significant anti-leukemia effects in the treatment of AML than curcumin or As2O3 monotherapy by up-regulating p53 pathway and down-regulating the JAK2/STAT3 pathway.

Pair Name	Capsaicin, Arsenic trioxide
Partner Name	Capsaicin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	DIABLO	hsa56616
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	HL-60	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_0002
In Vitro Model	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
Result	Combination index (CI) values were < 1 in all matched combination groups. Additional evaluation of As2O3 combined with ACM as a potential therapeutic benefit for AML seems warranted.